## Metadata * Author: [[Peter MD]] * ASIN: B0B1BTJLJN * ISBN: B0BZTCPLP6 * Reference: https://www.amazon.com/dp/B0B1BTJLJN ## Highlights Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. — location: [154](kindle://book?action=open&asin=B0B1BTJLJN&location=154) ^ref-44252 --- more of a disease process than an acute illness — location: [250](kindle://book?action=open&asin=B0B1BTJLJN&location=250) ^ref-43101 --- The typical cholesterol panel that you receive and discuss at your annual physical, along with many of the underlying assumptions behind it (e.g., “good” and “bad” cholesterol), is misleading and oversimplified to the point of uselessness. It doesn’t tell us nearly enough about your actual risk of dying from heart disease—and we don’t do nearly enough to stop this killer. — location: [259](kindle://book?action=open&asin=B0B1BTJLJN&location=259) ^ref-15247 --- While books like this always trumpet the fact that lifespans have nearly doubled since the late 1800s, the lion’s share of that progress may have resulted entirely from antibiotics and improved sanitation, — location: [441](kindle://book?action=open&asin=B0B1BTJLJN&location=441) ^ref-27553 --- Our tactics in Medicine 3.0 fall into five broad domains: exercise, nutrition, sleep, emotional health, and exogenous molecules, meaning drugs, hormones, or supplements. — location: [768](kindle://book?action=open&asin=B0B1BTJLJN&location=768) ^ref-1274 --- I do not shy away from pharmaceutical drugs because they are not “natural.” — location: [770](kindle://book?action=open&asin=B0B1BTJLJN&location=770) ^ref-28683 --- I used to prioritize nutrition over everything else, but I now consider exercise to be the most potent longevity “drug” in our arsenal, in terms of lifespan and healthspan. The data are unambiguous: exercise not only delays actual death but also prevents both cognitive and physical decline, better than any other intervention. We also tend to feel better when we exercise, so it probably has some harder-to-measure effect on emotional health as well. — location: [780](kindle://book?action=open&asin=B0B1BTJLJN&location=780) ^ref-24641 --- female centenarians outnumber males by at least four to one, — location: [986](kindle://book?action=open&asin=B0B1BTJLJN&location=986) ^ref-22116 --- women live longer but tend to be in poorer health. — location: [992](kindle://book?action=open&asin=B0B1BTJLJN&location=992) ^ref-26945 --- having more muscle mass, on average, which is highly correlated to longer lifespan and better function, — location: [993](kindle://book?action=open&asin=B0B1BTJLJN&location=993) ^ref-52771 --- Medicine 2.0 often drags out lifespan in the context of low healthspan, it lengthens the window of morbidity, the period of disease and disability at the end of life. People are sicker for longer before they die. — location: [1006](kindle://book?action=open&asin=B0B1BTJLJN&location=1006) ^ref-40636 --- why I test all my patients for their APOE genotype, — location: [1052](kindle://book?action=open&asin=B0B1BTJLJN&location=1052) ^ref-36313 --- Out of a conservatively estimated 100 million Americans who meet the criteria for the metabolic syndrome (i.e., metabolically unhealthy), almost exactly one-third are not obese. — location: [1510](kindle://book?action=open&asin=B0B1BTJLJN&location=1510) ^ref-11226 --- Some research suggests that these people might be in the most serious danger. A large meta-analysis of studies with a mean follow-up time of 11.5 years showed that people in this category have more than triple the risk of all-cause mortality and/or cardiovascular events than metabolically healthy normal-weight individuals. — location: [1512](kindle://book?action=open&asin=B0B1BTJLJN&location=1512) ^ref-62858 --- I insist my patients undergo a DEXA scan annually—and I am far more interested in their visceral fat than their total body fat. — — location: [1579](kindle://book?action=open&asin=B0B1BTJLJN&location=1579) ^ref-16741 --- I watch the ratio of triglycerides to HDL cholesterol (it should be less than 2:1 or better yet, less than 1:1), as well as levels of VLDL, a lipoprotein that carries triglycerides—all of which may show up many years before a patient would meet the textbook definition of metabolic syndrome. — location: [1721](kindle://book?action=open&asin=B0B1BTJLJN&location=1721) ^ref-50060 ---